Both normal and myeloma abdominal fat and bone marrow cell samples were obtained with the free and informed consent of the donorspatients, in accordance with the ethical. Annalisa has also joined the bone marrow transplant team at the saint antoine hospital in paris, france where she works as a staff physician, while continuing her research activities in stem cell transplanatation. Clinical impact of nkcell reconstitution after reduced intensity conditioned unrelated cord blood transplantation in patients with acute myeloid leukemia. Circulating follicular helper t cells are increased in. This page was last edited on 22 february 2020, at 10. Current research in translational medicine editorial board. Hopital saint antoine service hematologie, paris, france. Intrabone injection of cord blood cells ibucbt and doubleucbt ducbt are designed to circumvent this problem. Ebmt paris office, hospital saint antoine, paris, france. This randomized clinical trial compares the effectiveness of platelets in additive solution treated with amotosalenuva vs untreated platelets in plasma or in additive solution in patients with thrombocytopenia and malignant hematologic diseases. This map visualizes which other institutions researchers from hopital saintantoine hopitaux universitaires est parisien have collaborated with. Real life use of raltegravir during pregnancy in france. Treatment of chronic graft versus host disease with arsenic trioxide gvhdato the safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
All structured data from the file and property namespaces is available under the creative commons cc0 license. Treatment of chronic graft versus host disease with. Publications home of jama and the specialty journals of the. A study of idasanutlin with cytarabine versus cytarabine. My main center of interests are bone marrow transplantation, lymphoma, infectious complications and immunology. His main interests focus on myeloma treatment and biology. Association of lasparaginasemethotrexatedexamethasone for nasal and nasaltype natural killer nktcell lymphoma the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Il prend en charge les hemopathies myeloides du sujet age. The conventional apl includes lupus anticoagulant, anticardiolipin iggm antibodies and anti.
The control group consisted of 30 healthy individuals interventions. Hopital saint antoine service hematologie paris, france. This multicenter, openlabel, singlearm study will evaluate the safety and efficacy of obinutuzumab alone or in combination with chemotherapy in participants with previously untreated or relapsedrefractory chronic lymphocytic leukemia cll. Thrombotic thrombocytopenic purpura ttp is fatal in 90% of patients if left untreated and must be diagnosed early to optimize patient outcomes. Bone marrow transplantation center, the first affiliated hospital, school of medicine, zhejiang university, hangzhou, china. Eculizumab for catastrophic antiphospholipid syndromea. Nov 21, 2019 this has been updated in the html and pdf versions of this article. Antithymocyte globulin for graftversushost disease. Hopital saintantoine 184 rue du faubourg saintantoine, 75012 paris 01 49 28 20 00 bus n 46. May 29, 2018 fecal microbiota transplantation is an effective treatment in recurrent clostridium difficile infection. Hematologie clinique et therapie cellulaire hopital saintantoine.
Therapeutics alexandra hospital, athens, greece from 62014 to 62017 were enrolled. Annalisa has participated as a speaker of many international conferences and she is an active. Files are available under licenses specified on their description page. Service dhematologie clinique et therapie cellulaire hopital saint. Supplementary appendix this appendix has been provided by the authors to give readers additional information about their work. The abbey was abolished in 1790 and the monastery assigned to the saint antoine hospital in 1795. Department of infectious and tropical diseases, saint. Sir, aps is characterized by the presence of thrombosis andor obstetrical adverse events and persistent apl. Female donors for male recipients worsens outcome of allogeneic haematopoietic stem cell transplantation hsct. Predictive features of severe acquired adamts deficiency in. Outcomes of allogeneic hematopoietic cell transplantation for. Hpc authorized transplant centres france paris cedex 12 hopital saintantoine cod. Find out more about the editorial board for current research in translational medicine. To date, assays exploring adamts activity require skill and are limited to only some specialized reference laboratories.
Request permission export citation add to favorites track citation. The full spectrum of tma can be encountered in the course of sle. All patients fulfilled the 20 american college of rheumatologyeuropean league against rheumatism criteria for ssc. Despite improved management of caps due to an expeditious diagnostic process and the triple combination therapy, some refractory cases still occur and no large datasets are available about the management of these refractory caps patients. Saintantoine hospital map france to print and to download in pdf. Posttransplant cyclophosphamide for graftversushost. Hct2 in patients with acute lymphoblastic leukaemia all. Preemptive rituximab infusions after remission efficiently prevent. This is a phase 2b, singlearm, openlabel, multicenter study of selinexor 80 mg plus dexamethasone 20 mg sd, both dosed twice weekly in each fourweek cycle, in patients with mm previously treated with lenalidomide, pomalidomide, bortezomib, carfilzomib, and daratumumab and refractory to prior treatment with glucocorticoids, an immunomodulatory. Anchor your quebec city experience with a stay at auberge saintantoine, where our warm, convivial atmosphere greets each guest upon arrival. Sign up for facebook today to discover local businesses near you.
Second allogeneic stem cell transplantation in patients. The efficacy of anticd33 immunoconjugates had been previously demonstrated for gemtuzumabozogamicin. Service d hematologie clinique, saintantoine hospital, aphp, sorbonne university, and inserm umrs 938, paris, france. Hct2 is a therapeutic option for patients relapsing after first hct allo. In this context, the early identification of a severe, antibodymediated, adamts deficiency may allow to start targeted therapies such as blymphocytesdepleting monoclonal antibodies.
Posttransplant cyclophosphamide vs antithymocyte globulin. Unimpaired terminal erythroid differentiation and preserved enucleation. Hp, hematologie clinique et therapie cellulaire, hopital saint. Methodsin a retrospective registrybased analysis, we compared outcomes of 87 ib. The suburb was the location of the battle of the faubourg st antoine on 2 july 1652.
Service dhematologie clinique et therapie cellulaire hopital. Unimpaired terminal erythroid differentiation and preserved. To study the effect of splenectomy in hairy cell leukemia, we initiated a retrospective multicenter analysis. Rapid selftests whose use is becoming more common in france could help increase access to testing, yet could fail to diagnose hiv during acute hiv infection ahi.
Umbilical cord blood ucb emerged in the last 20 years as a valid alternative source of hematopoietic stem cell hsc in allogeneic transplantation setting, mainly in the absence of a fully human leucocyte antigen hla. Systemic dysfunction of osteoblast di adiposederived stem. Severe adamts deficiency occurs in % to 75% of thrombotic microangiopathies tma. Myeloma bone marrows were collected by sternal puncture. Elevated fatty liver index as a risk factor for all. We thank all the colleagues from the departments of hematology or internal medicine of the university hospitals of dijon, nantes, paris saint antoine, and tours, who contributed to the diagnosis and care of patients in this study. Listing a study does not mean it has been evaluated by the u. For information relating to your personal data and administrative management of your patient record. Phase i trials of ave9633 were performed in patients with aml to evaluate tolerability, pharmacokinetics and pharmacodynamics. Derivation of prediction model for treatment failure risk in. Serial samples from a cohort of multitransfused patients with hemoglobinopathies and a crosssectional population of pregnant women were tested for b19 markers.
Association of lasparaginasemethotrexatedexamethasone. Prognostic factors in waldenstrom macroglobulinemia. Hopital saintantoine hopitaux universitaires est parisien. Backgroundunrelated cord blood transplantation ucbt is associated with delayed hematopoietic recovery. Transplant outcomes for secondary acute myeloid leukemia. A safety and efficacy study of obinutuzumab alone or in. Oncotarget bcl2l10 positive cells in bone marrow are an.
The accident at the public general hospital in epinal is the more severe. A study of idasanutlin with cytarabine versus cytarabine plus placebo in participants with relapsed or refractory acute myeloid leukemia aml mirros the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Antoine crsa, sorbonne universites, upmc univ paris 06, paris, france. Service dhematologie clinique et therapie cellulaire. Although second allogeneic haematopoietic cell transplantation allo. This means that the hospital does not receive funding to cover the costs of this drug. This has been corrected in both the pdf and html versions of the original article. Fri0302 systemic lupus erythematosusassociated thrombotic. Expert statement on the icu management of patients with. Aug 01, 2000 prognostic factors in waldenstrom macroglobulinemia. Reactive hemophagocytic syndrome in adults american journal of. A series of 391 patients, contributed by 22 centers median. Saintantoine hospital map map of saintantoine hospital. Three phase i studies of ave9633 were performed in 54 patients with refractoryrelapsed aml.
Apr 19, 2016 a study evaluating s 95005 plus bevacizumab and capecitabine plus bevacizumab in patients with previously untreated colorectal cancer who are noneligible for intensive therapy full text view. This is just one of the solutions for you to be successful. Objectives hiv testing is an important step towards diminishing incident infections. Apr 26, 2011 the efficacy of anticd33 immunoconjugates had been previously demonstrated for gemtuzumabozogamicin. Abstract previous observations have reported controversial conclusions regarding cell dose and survival endpoints after allogeneic hematopoietic stem cell transplantation hsct.
Selinexor treatment of refractory myeloma full text view. However, the very low incidence of ttp is an obstacle to the development of evidencebased clinical practice recommendations, and the very wide variability in survival rates across centers may be partly ascribable to differences in management. Physician at the hematology department in saint antoine hospital, paris, france. Promising results to eradicate multidrugresistant bacteria have also been reported with this procedure, but there are safety concerns in immunocompromised.
Hematological disorders include leukemia, thrombocytopenia, anemia, leucocytopenia and more. Physician at the hematology department in saint antoine. He did his medical studies as well as his training in paris. Standardized case report form crf assessing disease status and parameters, was completed at baseline and at 3 months post treatment initiation. Impact of hla in cord blood transplantation outcomes.
View enhanced pdf access article on wiley online library html view download pdf for offline viewing. The socalled catastrophic aps caps is a very rare entity, which affects only 1% of aps patients, and presents as acute multiorgan failure. Exome sequencing identifies germline variants in dis3 in. Antithymocyte globulin for graftversushost disease prophylaxis in patients with intermediate or highrisk acute myeloid leukaemia undergoing reducedintensity conditioning allogeneic stem cell transplantation in first complete remission a survey on behalf of the acute leukaemia working party of the european society for blood and marrow transplantation. Umbilical cord blood ucb emerged in the last 20 years as a valid alternative source of hematopoietic stem cell hsc in allogeneic transplantation setting, mainly in the absence of a fully human le. Jci insight monoclonal igg in mgus and multiple myeloma. Saint antoine hospital, department of haematology and cellular therapy, paris. This clinic treats diseases of the blood, bone marrow, ganglions and spleen. Clinical impact of nkcell reconstitution after reduced. Thirteen ads were collected from the other hospital sites. This means that the hospital does not receive funding to cover the.
A museum hotel in the heart of old quebec city auberge saintantoine, a window into quebecs past. Eculizumab for catastrophic antiphospholipid syndromea case. Prognostic and longterm survival of immune thrombotic. Gut microbiota alteration during allogeneic haematopoietic.
Arnault tzancks name is attached to an apparatus he invented that was widely used for transfusing blood in france between the wars, as well a simple test he devised using the microscopic analysis of scrapings from skin cancer lesions, different ganglia, and some forms of dermatitis especially pemphigus. Acute leukemia working party of the european society for blood and marrow transplantation, saint. The new parish of saint antoine des quinzevingts was created on 4 february 1791 and received the abbey church as place of worship. Read the consultation guide pdf, in french look for a doctor or a service. Boutique hotel in old quebec city auberge saintantoine. The aim of the present study was to evaluate hivdetection sensitivity of a commonly used rapid selftest. Oct 15, 2005 recent reports suggested that parvovirus b19 b19 might persist in immunocompetent individuals such as blood donors, but only crosssectional data were available. Fecal microbiota transplantation before or after allogeneic. We wanted to find out whether a male hlamatched unrelated donor mud, 88, n2,014 might be an alternative to a female hlaidentical sibling donor n2,656 for males with acute leukaemia. Background the occurrence of a tma during sle is a rare event that complicates 1% to 4% of lupus. Biographyofantoinedesaintexupery pdf drive search and download pdf files for free. This has been updated in the html and pdf versions of this article. The use of antithymocyte globulin atg has represented the standard of care in graftversushost disease gvhd prophylaxis in patients undergoing a mismatched unrelated donor mmud transplant.
Teacher at sorbonne university pierre et marie cury. Service d hematologie clinique, saint antoine hospital, aphp, sorbonne university, and inserm umrs 938, paris, france. Ave9633 is an anticd33maytansine conjugate created by immunogen inc. Upfront autologous stem cell transplantation for newly diagnosed. Persistent b19 infection in immunocompetent individuals. Listing a study does not mean it has been evaluated by.
Metadata of the article that will be visualized in onlinefirst. Who is the best haematopoietic stem cell donor for a male. Abstract during the last 4 years, several incidentsaccidents at radiotherapy department occurred in france. Poster mopec 0599 real life use of raltegravir during. Today the former faubourg is divided by the rue du faubourg saintantoine between the 11th arrondissement of paris, which extends to the north of the road, and 12th arrondissement, which extends to the south.